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KMID : 0374019830060030149
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Ewha Medical Journal
1983 Volume.6 No. 3 p.149 ~ p.156
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Acute Effect of Methylprednisolone in Experimental Spinal Cord Injury
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Abstract
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It is the, purpose of this study to determine the benificial effect of treatment with methylprednisolone on the enhancement of Na+ K+-ATPase activity and the increased ATP level during the 4 hours after a ´ 400 gm cm injury W the spinal cord of at.
These results demonstrate that high dose (30 mg/ kg) of methylprednisolone can benificially enhance the activity of neuronal Na+ K ATPase during the first 4 hour after spinal cord injury. But the enhancement of this enzyme activity is not -significantly increased with -mega dose (60 mg / kg) of methylprednisolone.
Tissue level of ATP in the high dose treated cat at 1 hour after trauma was significantly elevated, but those in high dose-treated cat at 4 hour and the 1 and 4 hours with mega dose treated groups were not significantly increased.
The protective effects of methylprednisolone in experimental spinal cord trauma are the enhancement of Na+ K+-ATPase, inhibition of the free- radical reaction and the lipid peroxidation, the increment of neuronal activity and ATP utilization FEgh dose (30 mg /kg) of methylprednisolone is required in order to produce the acute effect in the early phase experimental spinal cord injury.
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